We try to get together as a group at least once a month to enjoy activities outside the lab. The Island is perfect for a variety of seasonal extracurricular events, such as skating, skiing, swimming, scuba diving, and of course, the occasional barbeque. Please click here or on the picture for some descriptions and pictures of our most recent group outings! | ||||
Research and Office Staff |
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![]() Russ Kerr
Professor
Phone: 902-566-0565
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Brad Haltli
Research Manager
Phone: 902-418-5125
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Postdoctoral Researchers | ||||
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Graduate Students | ||||
![]() Logan MacIntyre
PhD Student
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![]() Anna Kuznetsova PhD Student
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![]() Vernon Ptycia-Lamky MSc Student
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Hope Igboeli
PhD Student
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![]() Zach Maw
PhD Student
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Learn more about members of the Marine Natural Product Laboratory
1. Tangerina M.P., Correa H., Haltli B., Vilegas W., Kerr R.G. Bioprospecting from cultivable bacterial communities of marine sediment and invertebrates from the underexplored Ubatuba region of Brazil. Arch Microbiol. 2017 199: 155-169.
2. McCauley E.P., Haltli B., Correa H., Kerr R.G. Spatial and temporal investigation of the microbiome of the Caribbean octocoral Erythropodium caribaeorum. FEMS Micro Ecol. 2016 92: pii: fiw147. doi: 10.1093/femsec/fiw147.
3. Robertson V.*, Haltli B.*, Overy D., Kerr R.G. Highly variable bacterial communities associated with the octocoral Antillogorgia elisabethae. Microorganisms 2016 4: pii:E23. doi: 10.3390/microorganisms 4030023.
4. Pastrana-Camacho N., Suárez Z., Acosta-González A., Arango C., Haltli B., Correa H., Kerr R.G., Duque C., Diaz L.E. Bioprospecting for culturable actinobacteria with antimicrobial properties isolated from rivers in Colombian Orinoquia. Trop J Pharm Res. 2016 15: 1259-1265.
5. Sommer B., Overy D.P., Haltli B., Kerr R.G. Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities. Microbiology 2016 162: 1069-79.
6. Herzog B., Overy D.P., Haltli B., Kerr R.G. Discovery of keratinases using bacteria isolated from marine environments. Syst Appl Microbiol. 2016 39: 49-57.
7. Arens J.C., Haltli B., Kerr R.G. Draft Genome Sequence of Kitasatospora griseola Strain MF730-N6, a Bafilomycin, Terpentecin, and Satosporin Producer. Genome Announc. 2015 3: e00208-15.
8. McCauley E.P., Haltli B., Kerr R.G. Description of Pseudobacteriovorax antillogorgiicola gen. nov., sp. nov., a bacterium isolated from the gorgonian octocoral Antillogorgia elisabethae, belonging to the family Pseudobacteriovoracaceae fam. nov., within the order Bdellovibrionales. Int J Syst Evol Microbiol. 2015 65: 522-30.
9. Duncan K.R., Haltli B., Gill K.A., Correa H., Berrué F., Kerr R.G. Exploring the diversity and metabolic potential of actinomycetes from temperate marine sediments from Newfoundland, Canada. J Ind Microbiol Biotechnol. 2015 42: 57-72.
10. Janso J.E., Haltli B.A., Eustáquio A.S., Kulowski K., Waldman A.J., Zha L., Nakamura H., Bernan V.S., He H., Carter G.T., Koehn F.E., Balskus E.P. Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica. Tetrahedron. 2014 70: 4156-4164.
11. Duncan K., Haltli B., Gill K. A., Kerr R.G. Bioprospecting from marine sediments of New Brunswick, Canada: exploring the relationship between total bacterial diversity and Actinobacteria diversity. Mar Drugs. 2014 12: 899-925.
12. Correa H., Haltli B., Duque C., Kerr R.G. Bacterial communities of the gorgonian octocoral Pseudopterogorgia elisabethae Microb Ecol. 2013 66: 972-85.
13. Pike R.E., Haltli B., Kerr R. G. Description of Endozoicomonas euniceicola sp. nov. and Endozoicomonas gorgoniicola sp. nov., bacteria isolated from the octocorals Eunicea fusca and Plexaura sp., and an emended description of the genus Endozoicomona. Int J Syst Evol Microbiol. 2013 63: 4294-4302.
14. McCulloch M. W. B., Haltli B., Marchbank D. H., Kerr R. G. Evaluation of pseudopteroxazole and pseudopterosin derivatives against Mycobacterium tuberculosis and other pathogens. Mar Drugs. 2012 10: 1711-1728.
15. McCulloch M.W.B., Berrue F., Haltli B., Kerr R.G. One-pot syntheses of pseudopteroxazoles from pseudopterosins: a rapid route to non-natural congeners with improved antimicrobial activity. J Nat Prod. 2011 74: 2250-2256.
16. Jiang H., Haltli B., Feng X., Cai P., Summers M., Lotvin J., He M. Investigation of the biosynthesis of the pipecolate moiety of neuroprotective polyketide meridamycin. J Antibiot 2011 64: 533-538.
17. Berrue F., Withers S. T., Haltli B., Withers J., Kerr R.G. Chemical screening method for the rapid identification of microbial sources of marine invertebrate-associated metabolites. Mar Drugs. 2011 9: 369-381.
18. Liu H., Jiang H, Haltli B., Kulowski K., Muszynska E., Feng X., Summers M., Young M., Graziani E., Koehn F., Carter G. T., Min H. Rapid cloning and heterologous expression of the meridamycin biosynthetic gene cluster using a versatile Escherichia coli-Streptomyces artificial chromosome vector, pSBAC. J Nat Prod. 2009 72 (3): 389-395.
19. Ratnayake A. S., Haltli B., Feng X., Bernan V. S., Singh M. P., He H., Carter G.T. Investigating the biosynthetic origin of the nitro group in pyrrolomycins. J Nat Prod. 2008 71 : 1923–1926.
20. He M., Haltli B., Summers M., Feng X., Hucul J.A. Isolation and characterization of the meridamycin biosynthetic gene cluster from Streptomyces species NRRL 30748. Gene. 2006 377: 109-118.
21. Magarvey N. A., Haltli B., He M., Greenstein M. and Hucul J.A. Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens. Antimicrob Agents Chemother. 2006 50: 2167-2177.
22. Haltli B., Tan Y., Magarvey N.A., Wagenaar M., Yin X., Greenstein M., Hucul J.A., Zabriskie T.M. Investigating beta-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins. Chem Biol. 2005 12(11): 1163-1168.
23. Ritacco F. V., Haltli B., Janso J. E., Greenstein M., Bernan V.S. Dereplication of Streptomyces soil isolates and detection of specific biosynthetic genes using an automated Ribotyping instrument. J Ind Microbiol Biotechnol. 2003 30: 472-479.
Research Interests:
Research Interests:
I am a driven natural product chemist with a strong interest in mass spectrometry and the discovery and development of new bioactive natural products and their analogues from both marine and terrestrial sources. Completing my BSc at the University of Bangor in north Wales, an area of outstanding natural beauty, cultivated my interest for natural products which lead to my PhD studies at the University of St Andrews under the supervision of Professor Rebecca Goss. My current research focuses on identification, isolation, and structural elucidation of novel natural products along with the development of accessing silent or cryptic biosynthetic pathways.
Education:
2015 - 2019 - PhD Chemistry, University of St Andrews, Scotland, United Kindgom
2012 - 2015 - BSc Chemistry, University of Bangor, Wales, United Kingdom
Publications:
M. M. LeClair, Z. Maw, A Grunwald, J. R. Kelly, R.G. Kerr and C. Cartmell*. The Levesquamides: A Family of Isothiazoline Natural Products. Submitted to Marine Drugs 2022
C. Cartmell, A. L. Grunwald, C. Arango, N. J. Duncan, B. A. Haltli, L. E. Diaz and R. G. Kerr, Draft Genome Sequence of Streptomyces sp. RKCA744 Isolated from the Arauca River, Colombia. Microbial Resource Announcements. 2022
E. Pope, C. Cartmell, B. A. Haltli, R.G. Kerr and A. Ahmadi. Microencapsulation and In-SituIncubation to Improve the Recovery of Bacteria from Marine Habitats. Frontiers in Microbiology 2022
C. Cartmell, S. K. Wheatly, B. A. Haltli, R.G. Kerr and A. Ahmadi. Development of a Micro-Microbe Domestication Pod for In-Situ Cultivation. RSC advances 2022
Z. S. S. Al-Taie, C. Cartmell, R. T. Froom, R. G. Kerr, P. J. Murphy* and A. van Teijlingen. Synthesis of (+)-(R)-Tiruchanduramine. Molecules 2022
E. Naseri, C. Cartmell, M. Saab, R. G. Kerr and A. Ahmadi. Development of NOCC-Starch Biomaterial Inks for 3D Printed Wound Dressing Applications. Macromolecular Biosciences. 2021
A. L. Grunwald, C. Cartmell, R. G. Kerr. Auyuittuqamides A-D, Cyclic Decapeptides from Sesquicillium microsporum RKAG 186 Isolated from Frobisher Bay. Journal of Natural Products. 2020
T. Alkayyali, E. Pope, S. K. Wheatley, C. Cartmell, B. A. Haltli, Russ G. Kerr, and A. Ahmadi. Development of Microbe Domestication Pod (MD Pod) for In-Situ Cultivation of Micro-encapsulated Marine Bacteria. Biotechnology and Bioengineering. 2020
C. Cartmell, A. Abou Fayad, R. Lynch, S. V. Sharma, N. Hauck, B. Gust, R. J. M. Goss. SynBio-SynChem Approaches to Diversifying the Pacidamycins through the Exploitation of an Observed Pictet- Spengler Reaction. ChembioChem, 2020
E. Naseri, C. Cartmell, M. Saab, R. G. Kerr and A. Ahmadi. Development of 3D printed drug-eluting scaffolds for preventing piercing infection. Pharmaceutics, 12, (9), 901, 2020
C. Cartmell, C. Pubill-Ulldemolins, S. V. Sharma, J. Zhao, P. Cárdenas, R. J. M. Goss. Diversification Through Heck Cross-Coupling of Indole-Based Substrates in H2O: From Unprotected Halotryptophans to Halotryptophans in a Natural and a New to Nature Natural Product. Chemistry, a European journal. (25) 2019
Y. Renault, R. Lynch, E. Marelli, S. V. Sharma, J. Sharp, C. Cartmell, P. Cárdenas, R. J. M. Goss. Buchwald Hartwig Diversification of Unprotected Halotryptophans, Halotryptophan Containing Tripeptides and the Natural Product Barettin in Aqueous Conditions. Chemical communications. 2019
C. Cartmell, D. M. Evans, J. M. L. Elwood, H. S. Fituri, P. J. Murphy T. Caspari, B. Poniedziałek, P. Rzymski. Synthetic Analogues of Cyanobacterial Alkaloid Cylindrospermopsin and Their Toxicological Activity. Toxicology In Vitro. (44): 172-181. 2017
M. J. Corr, S. V. Sharma, C. Pubill-Ulldemolins, R. T. Bown, P. Poirot, D. R. M. Smith, C. Cartmell, A. Abou Fayad, R. J. M. Goss. Sonogashira Diversification of Unprotected Halotryptophans, Halotryptophans Containing Tripeptides and Generation of a New to Nature Bromo-Natural Product and its Diversification in Water. Chemical Science. (8): 2039-2046. 2017
S. V. Sharma, X. Tong, C. Pubill-Ulldemolins, C. Cartmell, E. J. A. Bogosyan, E. J. Rackham, E. Marelli, R. B. Hamed, R. J. M. Goss. Living GenoChemetics by Hyphenating Synthetic Biology and Synthetic Chemistry In Vivo. Nature Communications. (8) 2017
Contact:
Email: ccartmell@upei.ca
Phone: 1-902-620-5035
Former Lab Members |
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![]() Kelly Richard
Research assistant
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![]() Jeanna McLeod
BSc 2011
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Saskia Hart
Research Assistant
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Katherine Duncan
PhD 2012
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![]() Katheryn Hay
BSc 2012
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![]() Christie Ings
BSc 2012
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![]() Jeanetta McGinley
BSc 2012
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![]() David Forner
BSc 2012
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![]() Troy Cumberlach
Visiting Student 2011-2012
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![]() Ann Hanseebaran
Visiting Student 2011-2012
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![]() Andi Hanif
Post Doc 2011-2012
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![]() Quinn Gill
Summer Student 2013
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Research Interests:
Goldberg S., Mueller S., Brichetti J., Sadoff J. Cryo-preserved Whole Blood (WB) for use in Cell Mediated Immunity (CMI) Assays, Poster on behalf of Aeras Global TB Vaccine Foundation. TB Vaccines for the World Conference, Atlanta, GA (2008).
Casey, J.R., Aucan J.P., Goldberg S.R., Lomas M.W. Changes in partitioning of carbon amongst autotrophic pico- and nanoplankton groups in response to changes in the North Atlantic Oscillation. Deep Sea Research II: Topical Studies in Oceanography (Feb 2013).
Goldberg, S. Advancement of molecular methods for identification of bromotyrosine alkaloid derivatives from marine sponges and assessment of their therapeutic potential. Graduate Studies and Research Days, AVC, University of Prince Edward Island (2013). Gold Prize Award.
2011-2013 Chemical Engineering, Hainan University
2013-present (transfer) Chemistry(Undergraduate), UPEI
Fun Events Outside the Lab
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Kerr Lab Christmas 2014 The lab spent the evening celebrating the holiday season with good food and drink and a gift exchange. |
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Kerr curling outing The lab spent the afternoon at the rink on April 1st 2012 |
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1st Kerr Golf Tournament The lab spend the afternoon at the green for the first annual Kerr Golf Tournament on June 24th 2011 |
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Deep Sea Fishing Adventure The lab tried out their fishing techniques at Wade's Deep Sea Fishing in September 2010 |
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Maritime Natural Products Conference 2010 The second annual Maritime Natural Products Conference was held at UPEI August 31 - September 2, 2010 |
Lab Retreat 2010 First Annual Kerr Group Lab Retreat at Camp Riverdale July 2010 |
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Football at Greenwich National Park
Our football skills were put to the test on this blustery day in late May, 2009. The boardwalk was beautiful, the scenery was stunning, the air was fresh, and the food at PEI's best "Fish & Chips" spot was delicious!
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Skating on the "Puddle"
Every now and again the unversity campus acquires its own pond, which is really nothing more than a huge puddle. This November, we decided to test our skating skills -- for some of us it was the first time in years! It was a lunch break to remember!
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Skiing at Brookvale
Our lab members come from many different countries. Some of them saw snow for the first time this winter! We decided to give them a true PEI welcome at Brookvale Provincial Ski Park.
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IUPAC Conference
On July 13th to 18th, 2008, we hosted the IUPAC Conference on Biodiverstiy and Natural Products. The program included plenary lectures, invited lectures, and Oral/Poster presentations, as well as plenty of opportunities to tour our beautiful island! The conference finale included a catered lobster meal on a beach.
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Bioquest
On October 17, 2008, the Kerr group participated in Bioquest, during which 200 grade five students from around the Maritimes are invited to come and enjoy hands-on demonstrations of science in the real world. We had a fantastic day with these young and enthusiastic learners.
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Party at the Cottage!
We kicked off the summer of 2008 in style at Russ and Stacey's cottage. There was badminton, soccer, swimming, boating,clam-eating, and of course, a delicious barbeque on the deck!
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